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What is Alpha-1 Antitrypsin Deficiency?

Alpha-1 Antitrypsin Deficiency also known as Alpha-1, A1AD or AATD is an inherited, genetic condition that is passed on from generation to generation. As the name suggests it is a deficiency of alpha-1 antitrypsin (AAT) in the bloodstream. AAT is an enzyme produced in the liver to help protect the tissues of the body during infections. The low level of AAT in the blood occurs because the AAT is abnormal and cannot be released from the liver at the normal rate. This leads to a build up of abnormal AAT in the liver that can cause liver disease and a decrease of AAT in the blood that can lead to lung disease.

Newsletter Autumn 2018 Now Available

Autumn 2018 Alpha-1 UK Newsletter Issue 17
Now Available

Contains 36 pages full of News and Information including:

21 years Alpha-1 UK Support Coming of Age, Research & Global Congress update, Members Stories and much more


Top Story

Keith Pollard is kindly donating the net proceeds of his book to the Alpha-1 UK Support in memory of his son Jason 


This remarkable new autobiography recalls the days when rugby league could be brutal and was regularly described as ‘The toughest sport in the World.’

It follows Keith from his days at Hull KR in the mid-sixties where he packed down with legends such as Peter Flanagan and Frank Foster, to the climax of his unique career, playing for Maitland in Australia during the seventies, in the highly competitive Newcastle league.

‘We thought he was a god from another planet’ said Maitland team mate and later Hull FC coach, Peter Sharp, after Keith had played and won in two Grand Finals.

But ‘Red & White Phoenix’ is far more than just a sporting memoir. Keith’s playing days provide the centre piece of a finely woven story, containing tales from Hull’s illustrious history, memories of youthful exuberance, anecdotes from a fascinating working life and a heart-breaking account recalling the tragic death of his son Jason.

ISBN: 9781916429420

Price: £9.95 + £2 P&P



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Keith Pollard
05 Dec 2018 19:30Keith Pollard

Keith Pollard is kindly donating the net proceeds of his book to the Alpha-1 UK Support in memory of his son Jason    

This remarkable new  [ ... ]

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Westminster Hall Debate
27 Oct 2018 19:30

Dear Alpha-1 patients in the UK, WE NEED YOUR SUPPORT! URGENTLY! We are delighted to inform you that, further to Mark Pawsey MP’s attendance at ou [ ... ]

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Mark Pawsey Press Release
27 Oct 2018 19:30Mark Pawsey Press Release

Mark Pawsey MP raises awareness of rare illness in Parliament   Mark led the first ever parliamentary debate on Alpha-1 Antitrypsin Deficiency  [ ... ]

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Clinical trial update – 19th October 2018
20 Oct 2018 10:42

In light of very recent events, we would like to provide some important information about upcoming clinical trials in Alpha-1 in the UK. Currently, t [ ... ]

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