Alpha-1 Antitrypsin Deficiency also known as Alpha-1, A1AD or AATD is an inherited, genetic condition that is passed on from generation to generation. As the name suggests it is a deficiency of alpha-1 antitrypsin (AAT) in the bloodstream. AAT is an enzyme produced in the liver to help protect the tissues of the body during infections. The low level of AAT in the blood occurs because the AAT is abnormal and cannot be released from the liver at the normal rate. This leads to a build up of abnormal AAT in the liver that can cause liver disease and a decrease of AAT in the blood that can lead to lung disease.
Our Committee Member, Lindsay Jarrett visits Mereo Biopharma to highlight Alpha-1 community needs
26th November 2019
On 26 November 2019, Lindsay Jarrett, Committee Member of Alpha-1 UK Support Group, visited Mereo Biopharma at their offices in London. Following the Alpha-1 UK Support Group's Annual Social Gathering & Information Day on 14 September 2019 in Daventry, the Mereo team wanted to understand the true impact that Alpha-1 has in real life; and what it means in reality for people who are progressing rapidly along to serious lung disease at young age.